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Introduction
Premenstrual syndrome (PMS) affects up to 75% of women during their reproductive years, bringing disruptive symptoms like mood swings, irritability, bloating, and breast tenderness. Chasteberry (Vitex agnus-castus, or VAC) has long been a traditional herbal remedy. Recent clinical trials and reviews now shed light on how well it truly works—and whether it deserves a place in daily hormone support.
Meta-Analysis Evidence
A meta-analysis of placebo-controlled trials revealed women taking standardized Chasteberry extracts were 2.5x more likely to see PMS relief compared to placebo.
Clinical Trials
In one RCT with 170 women, 52% taking Chasteberry experienced a 50% symptom reduction, compared to only 24% in placebo.
Dose-finding studies show 20 mg/day of extract (Ze 440) is effective, while higher doses didn’t add extra benefits.
Systematic Reviews
Reviews conclude Chasteberry often performs as well as fluoxetine (an antidepressant) or pyridoxine (Vitamin B6), but with fewer side effects.
Benefits at a Glance
| Benefit | Clinical Evidence |
|---|---|
| PMS Symptom Relief | Reduced irritability, mood swings, and breast tenderness |
| Comparable to Drugs | Similar effects as fluoxetine, with fewer side effects |
| Optimal Dosage | 20 mg standardized extract per day |
| Safety | Mild side effects (headache, nausea) are rare |
Safety & Considerations
Avoid use during pregnancy or while on hormonal contraceptives.
Consult a healthcare provider if you have hormone-sensitive conditions or are on dopaminergic medications.
Why We Use It in
HerRhythm™ Regularity Complex
Greyz Labs’ Her Rhythm formula includes clinically dosed Chasteberry extract (20 mg) for daily support in balancing hormones, reducing PMS symptoms, and enhancing overall women’s wellness.
References
PubMed: Meta-analysis of Vitex for PMS
Thieme Journal: Clinical Trials Review
BMJ Trial: 170 Women RCT
Reproduct Endo: Dose-finding study Ze 440
AAFP & MSKCC: Safety & Commission E Approvals, MSKCC Chasteberry Info
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